Targeting Cell Survival Proteins for Cancer Cell Death

Targeting Cell Survival Proteins for Cancer Cell Death

Escaping from cell death is one of the adaptations that enable cancer cells to stave off anticancer therapies. The key players in avoiding apoptosis are collectively known as survival proteins. Survival proteins comprise the Bcl-2, inhibitor of apoptosis (IAP), and heat shock protein (HSP) families. The aberrant expression of these proteins is associated with a range of biological activities th...

Targeting the cell death-survival equation.

This issue of CCR Focus comprises four representative articles that closely fit the research interests of Stanley J. Korsmeyer, to whom this volume is dedicated. The first article, and perhaps the most related to Korsmeyer’s work, is a review by Nika Danial of the structure and function of the ever growing BCL-2 family of proteins and their potential role in disorders as apparently disparate as...

Neuronal death and survival - targeting glutamate-induced cell death mechanisms

Molecular Docking of Curcumin With Breast Cancer Cell Line Proteins

Background: Breast cancer is known as the most widely recognized dangerous tumors; therefore, the most common reason for mortality among all instances of harmful neoplastic illness in females. This is because the lack of specific signs and symptoms at the early stage and at the aggressive nature. Currently, breast cancer treatment such as chemotherapy, surgery and radiotherapy has not been effe...

Therapeutic Exploitation of Targeting Programmed Cell Death for Cervical Cancer

Programmed cell death (PCD) is a basic biological phenomenon that plays an important role during development, preservation of tissue homeostasis, and elimination of damaged cells. Several nomenclature systems have been proposed to classify PCD. One widely accepted system describes three major morphologies of programmed cell death, and classifies PCD as type I, apoptosis; type II, autophagy; and...